Research Focus
Our laboratory is interested in understanding the mechanisms of metabolic regulation in the heart and skeletal muscle.
Cellular energy homeostasis is central to cardiac and skeletal muscle function and development. Impaired capacity for energy production, as seen in patients with mutations in mitochondrial DNA or nuclear genes encoding lipid oxidation enzymes and respiratory chain components, can lead to cardiac and skeletal muscle dysfunction. An inability to match energy supply to energy needs is also seen in human heart failure and neuromuscular disorders. By contrast, restoring mitochondrial function has been shown to benefit heart failure. Our goal is to understand the molecular networks that regulate mitochondrial biogenesis, fueling, and function that may lead to future novel therapeutic targets for treating diseases associated with bioenergetic defects.
We are interested in studying how metabolism and metabolic pathways are altered and regulated under pathological conditions and in response to environmental stimuli. We employ animal and human cardiac and skeletal muscle cells and genetically engineered animal models for our studies. We also utilize a multidisciplinary approach using physiology, molecular biology, genetics, proteomics, and lipid profiling to study molecular changes under different stress and pathological conditions.
Our laboratory is interested in understanding the mechanisms of metabolic regulation in the heart and skeletal muscle.
Cellular energy homeostasis is central to cardiac and skeletal muscle function and development. Impaired capacity for energy production, as seen in patients with mutations in mitochondrial DNA or nuclear genes encoding lipid oxidation enzymes and respiratory chain components, can lead to cardiac and skeletal muscle dysfunction. An inability to match energy supply to energy needs is also seen in human heart failure and neuromuscular disorders. By contrast, restoring mitochondrial function has been shown to benefit heart failure. Our goal is to understand the molecular networks that regulate mitochondrial biogenesis, fueling, and function that may lead to future novel therapeutic targets for treating diseases associated with bioenergetic defects.
We are interested in studying how metabolism and metabolic pathways are altered and regulated under pathological conditions and in response to environmental stimuli. We employ animal and human cardiac and skeletal muscle cells and genetically engineered animal models for our studies. We also utilize a multidisciplinary approach using physiology, molecular biology, genetics, proteomics, and lipid profiling to study molecular changes under different stress and pathological conditions.
